Forkhead Box O4 (FOXO4) (C-Term) Peptide
FOXO4
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN977074
Quick Overview for Forkhead Box O4 (FOXO4) (C-Term) Peptide (ABIN977074)
Target
FOXO4
(Forkhead Box O4 (FOXO4))
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- PPVMAGAPIP KVLGTPVLAS PTEDSSHDRM PQDLDLDMYM ENLECDMDNI
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Foxo4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FOXO4 (Forkhead Box O4 (FOXO4))
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Background
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Foxo4 is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. It down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle. It represses smooth muscle cell differentiation by inhibiting the transcriptional coactivator activity of myocardin.
Alias Symbols: Afxh, MGC117660, Mllt7, afx
Protein Size: 505 -
Molecular Weight
- 54 kDa
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Gene ID
- 54601
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NCBI Accession
- NM_001005872, NP_001005872
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UniProt
- Q99MK2
Target
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